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UK SPINE Conference: The Age of Healthspan

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Beverley Vaughan

Programme Director, UK SPINE: Knowledge Exchange

Chas Bountra

Pro-Vice Chancellor for Innovation, University of Oxford

Phil Clare

Deputy Director, Research Services, University of Oxford

Lynne Cox

PI Lab of Ageing and Cell Senescence, Department of Biochemistry, University of Oxford

Heather Draper

Professor of Bioethics, Warwick Medical School, University of Warwick

Stuart Redding

Centre for Health Service Economics & Organisation, University of Oxford. Project Lead

Andrew Scott

London Business School and The Longevity Forum. Professor of Economics

Mike Ferguson

Regius Professor of Life Sciences, University of Dundee

Graeme Wilkinson

Head of Virtual R&D, Medicines Discovery Catapult

Michael Hopkins

Professor of Innovation Management, SPRU, University of Sussex Business School

Ghada Alsaleh

Kennedy Institute of Rheumatology, University of Oxford

Phil Atherton

Chair of Clinical, Metabolic & Molecular Physiology

James Edwards

Skeletal Ageing and Repair group, Botnar Research Centre, University of Oxford

John Overington

Chief informatics Officer, Medicines Discovery Catapult

Martino Picardo

Independent Consultant (Chairman, Discovery Park, VisusNano)

Felix Richter

Kennedy Institute of Rheumatology, University of Oxford

Malcolm Skingle

Director, Academic Liaison, GlaxoSmithKline

Clare West

Informatics Postdoctoral Researcher, UK SPINE, University of Oxford and Open Targets

Janet Lord

University of Birmingham, Director of the Institute of Inflammation and Ageing

Satomi Miwa

Lecturer for Translational biology of ageing, Biosciences Institute, Newcastle University

Frédérique Bone

Research Fellow, Science Policy Research Unit (SPRU), University of Sussex

Wen Hwa Lee

CEO and Chief Scientist Action Against AMD

Emma Fox

Programme Manager, Translation team at The Francis Crick Institute

Alexander Masters

Author and Co-founder of iCancer

Karl Morten

Director of Graduate Studies, Nuffield Department of Women’s and Reproductive Health

Ivan Pavlov

Medical Research Council, Population and Systems Medicine Board Secretary and Lead on Multimorbidity

Sara Ward

Chief Operating Officer, Oxford Academic Health Partners

Graham Russell

Emeritus Professor of Musculoskeletal Pharmacology, Oxford and Sheffield Universities

Ranulf Crooke

NHS General Practitioner and Co-founder of Crockett and Crooke Ltd

Thomas Jackson

Institute of Inflammation and Ageing

Helen Knowles

Senior Research Scientist, Medical Sciences Division, University of Oxford

Jesse Coker

Science and Strategy Associate, Action Against Age-Related Macular Degeneration

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The UK SPINE sets out to build a multi-lateral knowledge exchange network, concomitantly bringing together multi-disciplinary expertise from a range of HEIs, industry and the charitable sector, together with strong NHS partnerships focused on a common goal.



National network of research & clinical collaborators developing new medicines in healthy ageing, with Oxford, Birmingham, Dundee, the Crick & MD Catapult.

Creative Destruction Lab

Build Something Massive

Pharmaco-epidemiology for discovery of targets and modulating strategies to protect against age-related macular degeneration

Project lead: Wen Hwa Lee, Action Against Age-related Macular Degeneration (AAAMD)

The Impact on NHS Costs of Delaying the Onset of Multi-morbidity in Old Age (INCDOM)

Project lead: Stuart Redding, Centre for Health Services, Economics and Organisation, University of Oxford

Targeting Autophagy for the Treatment of Osteoarthritis

Project lead: Ghada Alsaleh, University of Oxford

Identifying factors that restore DNA repair in ageing cells through WRN reactivation

Project lead: Lynne Cox, Department of Biochemistry, University of Oxford

A translational pathway to address tissue hypoxia and its consequences using novel oxygen nanobubble delivery technology

Project lead: Professor Duncan Richards, Nuffield department of orthopaedics, rheumatology and musculoskeletal sciences, University of Oxford

Exploring the use of Raman microscopy to determine mitochondrial function and mitochondrial drug accumulation in aging model systems

Project lead: Karl Morten, University of Oxford

Committed Philanthropy

Project lead: Heather Draper, University of Warwick

Identifying potential targets for age-related multimorbidity

Project lead: Clare West, University of Oxford

Data Science X Biomedical Science Summer School with KQ Labs, Entrepreneurs First, the Alan Turing Institute, and the Francis Crick Institute

Project lead: Barbara Domayne-Hayman, The Francis Crick Institute

A Roadmap of Current Needs in Drug Discovery for Healthy Ageing

Project lead: Graeme Wilkinson, Medicines Discovery Catapult

Evaluation of epigenetic targets in ageing

Project lead: Panagis Filippakopoulos, University of Oxford

Impacts of Mechanistic Target of Rapamycin (mTOR) inhibition on aged human muscle

Project lead: Professor Philip Atherton, School of Medicine, University of Nottingham

Pre-clinical validation of novel candidate senolytics

Project lead: Dr Satomi Miwa, Professor Thomas von Zglinicki, Newcastle University

Accelerating Novel Treatments for Ageing and Age-Related Disease

Project lead: Thomas Jackson, University of Birmingham

Accelerating the Development of Drug Repositioning and Combination Therapies for Healthy Ageing

Project lead: John P. Overington, Medicines Discovery Catapult

Identification of Novel Epigenetic Targets to Re-activate Exhausted and Senescent T Cells

Project lead: Annette von Delft, University of Oxford

Identification of lipid mediators provided by autophagy that polarize anti-inflammatory macrophages

Felix Richter, Professor Katja Simon, Nuffield department of orthopaedics, rheumatology and musculoskeletal sciences, University of Oxford

Visualizing protein misfolding in brain ageing

Project lead: Dr Sonia Gandhi, the Francis Crick Institute

Ageing Therapeutics

Project lead: David Gray, University of Dundee

Targeting Age-Related Multi-Morbidities with Bisphosphonates

Project lead: James Edwards, University of Oxford

Novel Blood Biomarkers for Ageing Phenotypes

Project lead: James Edwards, University of Oxford and Eugene McCloskey, University of Sheffield

Biomarkers of Multimorbidity

Project lead: Carl Heneghan and Elizabeth Spencer, University of Oxford

Drug Discovery in Ageing

Project lead: Janet Lord, University of Birmingham

Efficient Lung Drug Delivery Systems

Project lead: Esra Sorguven, University of Sussex

Comprehensive and collaborative screening of small molecule inhibitors across a range of disease-specific assays in ageing and inflammation

Project lead: Cassandra Adams, Centre for Medicines Discovery, University of Oxford