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CMAC Virtual Open Day

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EPSRC Future Continuous Manufacturing and Advanced Crystallisation Research Hub (CMAC) is an international hub for excellence for medicines manufacturing research, comprising of 7 leading UK Universities, 8 global pharmaceutical partners and 17 technology companies. CMAC’s goal is to enable the pharmaceutical and chemical industries to deliver high quality products in a more economical, efficient, and sustainable manner, by advanced continuous manufacturing. The ambitious programme targets current and future needs by developing digital design and modelling methodologies as well as integrated, flexible, and modular end-to-end continuous processing. This approach involves product and process understanding of small molecule manufacturing, to meet the current industry demands for more personalised product performance for patients and consumers.

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Anatune Ltd

Providers of the only real-time residual solvent monitor in manufacturing process lines

Alconbury Weston Ltd

End-to-End solutions for Continuous Reaction, Crystallisation, Filtration and Drying


Fresh insight into effective pharmaceutical process plant cleaning


Advancing structural science.

Clairet Scientific Limited

Spectroscopy Tools for PAT - Raman, NIR, UV-Vis, FTIR

M-Star Simulations

Next level CFD simulations

NiTech Solutions Ltd

Advanced Manufacturing using NiTech Solutions Continuous Oscillating Baffled Reactors & Crystallizers

Perceptive Engineering Ltd

Optimising your process from development, to scale-up to manufacturing

PSE - A Siemens Business

Science-based digital twins for design & operation

Technobis Crystallization Systems – ‘Help Research Succeed’

Solid-state research, process development and formulation

ThermoFisher Scientific

The world leader in serving science

49. Deborah Bowering and Alan Martin

Structural investigation of water responsive materials

50. Thokozile Kathyola

X-ray scattering and X-ray Photoelectron Spectroscopy analysis of Mefenamic Acid thermal-induced polymorphism

51. Anuradha Pallipurath

Towards rational design and control of crystallisation processes

52. Aruna Prakash

ToF-SIMS in pharmaceutical manufacturing

53. Kenneth Smith

CMAC National Facility short case studies

54. Martin Ward

Recovery of high-pressure solid forms to ambient pressures

55. Monika Warzecha

Understanding the adsorption of impurities on crystal faces using molecular modelling and atomic force microscopy

56. Paul Anandan

Controlling batch crystallisation process using reinforcement learning

57. Thomas Bernet

SAFT-γ Mie modelling of groups and complex molecules; parameter estimation framework and performance

58. Suela Jonuzaj

Solvent mixture design and optimisation for the integrated crystallisation and isolation of Mefenamic Acid

59. Victor Portela

An immersive training environment for the assembly of an EasyMax chemical stirrer

60. Murray Robertson

Exploring the CMAC data strategy: digital workflows and risk mapping

61. Ettore Settanni

MicroFactory supply chain design

62. Vijay Srirambhatla

Machine learning approach for the prediction of glass-forming ability of pharmaceutical compounds

63. Antony Vassileiou

Combined AI techniques for particle sizing directly from microscope images

64. Bilal Ahmed

Spherical agglomeration: workflow development

65. Magdalene Chong

Temperature correction of UV spectra for improved concentration monitoring during cooling crystallisation

66. Frederik Doerr

Model-based design and optimisation of crystallisation processes: image analysis methodologies for small scale parameter estimation

67. Wei Li

Model-based design and optimization of multistage mixed suspension mixed product removal crystallization of Mefenamic Acid

68. Patricia Marce Villa

Feasibility workflow: integration of continuous synthesis and crystallisation

69. John McGinty

Developing a workflow for continuous antisolvent crystallisation

70. Ebenezer Ojo

Multistage, multi-zones antisolvent-cooling crystallisation of a proprietary API: Experimental comparison of effect of geometry and hydrodynamics in four batch crystallisers

71. John Totten

Impact of silk stock on nanoparticle assembly and characteristics

72. Maria Blazejczak

MMIC: Developing next-generation pharmaceutical manufacturing

73. Hikaru Jolliffe

Medicines Manufacturing Innovation Centre (MMIC): the use of a Digital Twin

74. Carlota Mendez

Development of methods to assess mixing efficiency in commercial tablet manufacture

75. Martin Prostredny

MMIC Grand Challenge 1 Process equipment and facilities

76. Sara Ottoboni

Understanding API static drying with hot gas flow: design and test of a drying rig prototype and drying modelling development

77. Elke Prasad

Improving consistency for a Mefenamic Acid immediate release formulation

12. Gunjan Das

Time-resolved microfocus synchrotron X-ray Phase Contrast Imaging (XPCI) – a versatile tool for predictive design and control of crystallisation processes

13. Michael Devlin

Structure and transformations in amorphous Paracetamol

14. Laura Pereira-Diaz

Coupling primary and secondary manufacturing via digital design of crystalline materials

15. Matthew Wilkinson

Applying machine learning to the prediction of crystal morphology

16. Siya Nakapraves

Machine learning approaches for predictive design of the crystal shape of Mefenamic Acid

17. Laura Straughair

Analysis of organic crystals containing solvents in the CSD

18. Oliver Watson

Computer-aided solvent selection for the control of crystal morphology of pharmaceutical compounds

19. Nura Abdallah

In situ monitoring of the cooling crystallisation of mefenamic acid using Raman, Terahertz-Raman and ATR-UV spectroscopies

20. Andrew Cashmore

A rapid and small-scale assessment of secondary nucleation and growth kinetics of α-glycine

21. James Flannigan

An investigation of secondary nucleation at the microscale using optical tweezing

22. Jenna Johnston

Model-driven controld for continuous crystallisation of α-Lactose Monohydrate

23. Victoria Kitching

The influence of vessel and agitator geometry and speed on flow characteristics in spherical agglomerators

24. Corin Mack

Thermodynamics in antisolvent phase diagrams: methodology development and molecular interactions

25. David McKechnie

Tuning dispersion interactions to control heterogeneous nucleation

26. Russell Miller

Modelling diffusive mixing in continuous antisolvent crystallisation

27. Mitchelle Mnemo

Digital design strategies for industrial crystallisation development

28. Pollyanna Payne

Benchmarking the CMAC additive and multicomponent workflows

29. Daniel Powell

Protein Nucleation in microfluidic devices

30. Jon Tew

A mechanistic study of wetting & nucleation in spherical agglomeration

31. Moulham Alsuleman

Material based decision for formulating a 3D printing filament

32. Ecaterina Bordos

Effect of material and process parameters on the microstructure of amorphous solid dispersions

33. Jack Creswick

Analysis of novel spherical agglomerate tablets: fragmentation quantification and impact on tablet performance

34. William Eales

Measuring and modelling agglomeration and breakage during agitated vacuum thermal drying

35. Peter Hou

Design of a micro-feeder for solid pharmaceuticals

36. John Mahon

Investigating structural changes of amorphous solid dispersions during dissolution

37. Keir Murphy

Analysis of terahertz scattering of granular materials

38. Georgia Sanxaridou

Mechanical properties of agglomerates produced by two different drying methods

39. Muhid Shahid

Employing constant rate filtration to improve active pharmaceutical ingredients (APIs) washing efficiency

40. Mariam Siddique

Quantification of granule formation during drying as a function of solubility in residual solvents

41. Mithushan Soundaranathan

Quantification of swelling characteristics of pharmaceutical particles

42. Pattavet Vivattanaseth

In situ monitoring of hot melt extrusion with Terahertz (THz) – Raman spectroscopy

43. Erin Walsh

Manufacturing tablets with desired specific surface area

44. Svetlana Bibiceva

Understanding auto-agglomeration in dry Active Pharmaceutical Ingredients

45. Bridgit Etbon

Understanding the impact of API particle size control methods on API Surface properties and the drug product sticking

46. Alexander Jackson

Solubility and nucleation of a homologous series of representative diesel n-alkanes (C16H34 – C22H46) in toluene & dodecane

47. Monty Reed

Demonstrating link between spray drying and single droplet drying

48. Vivian Walter Barron

Molecular modelling metered dose inhaler suspension formulations